5-Methyl-3-(pyridin-2-yl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide

Name	Droxicam
Synonyms	E-318 E-3128 Droxar Dobenam DROXICAM Droxicam 5-Methyl-3-(2-pyridyl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide 5-Methyl-3-(pyridin-2-yl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide
CAS	90101-16-9

Molecular Formula	C16H11N3O5S
Molar Mass	357.34
Density	1.68±0.1 g/cm3(Predicted)
Melting Point	259-261°
Boling Point	554.7±60.0 °C(Predicted)
Solubility	DMSO (Slightly), Methanol (Slightly, Heated)
Appearance	Solid
Color	Off-White to Pale Yellow
pKa	3.80±0.19(Predicted)
Storage Condition	2-8°C
Physical and Chemical Properties	Crystallized from acetone, melting point 259~261 ℃. Acute toxicity LD50 male and female mice, male and female mice (mg/kg):6192,8841,1434,1994 oral administration.

Toxicity

LD50 orally in male, female mice, and male, female rats: 6192, 8841, 1434, 1994 mg/kg (Soler, 1986)

Use	is a prodrug of piroxicam that functions in the stomach by conversion to piroxicam. For anti-inflammatory.
production method	by the compound (I) and phenyl N-(2-pyridyl) carbamate, it is obtained by refluxing in dipolyethylene glycol dimethyl ether.

Last Update：2024-04-09 21:54:55

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CAS: 90101-16-9
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5-Methyl-3-(pyridin-2-yl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide Request for Quotation